The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation
Identifieur interne : 003688 ( Main/Exploration ); précédent : 003687; suivant : 003689The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation
Auteurs : L. Binderup [Danemark] ; E. Bramm [Danemark] ; E. Arrigoni-Martelli [Danemark]Source :
- International Journal of Immunopharmacology [ 0192-0561 ] ; 1982.
English descriptors
- Teeft :
- Acetylsalicylic, Acetylsalicylic acid, Adherent, Adherent cells, Adjuvant, Adjuvant arthritis, Adjuvant disease, Antirheumatic, Antirheumatic drugs, Arthritic, Arthritic lewis rats, Arthritic rats, Arthritis, Arthritis rheum, Aurothiomalate, Binderup, Bramm, Ceils, Cell suspensions, Cell viability, Chloroquine, Chronic inflammation, Concanavalin, Control rats, Corresponding values, Days treatment, Immunological, Immunological reactivity, Immunological responsiveness, Indomethacin, Inflammation, Inhibitory effects, Levamisole, Lewis rats, Lymphocyte, Lymphocyte responsiveness, Macrophage, Mitogen, Myocrisin, Nonadherent, Nonadherent cells, Nonarthritic, Nonarthritic rats, Noninjected, Open bars, Plastic petri dishes, Polyarthritic lesions, Present experiments, Pyritinol, Rat, Rats nonarthritic nonarthritic, Rheumatoid, Rheumatoid arthritis, Separate experiments, Sodium aurothiomalate, Spleen, Spleen cell responsiveness, Spleen cell suspensions, Spleen cells, Suppressive, Suppressive activity, Suppressive macrophages, Suppressor, Suppressor cells, Unseparated, Unseparated spleen cells, Untreated, Untreated rats.
Abstract
Abstract: During the course of adjuvant arthritis in rats adherent spleen cells inhibited the response of spleen lymphocytes to the T-cell mitogen concanavalin A (Con A). The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs in vivo on immunological responsiveness during chronic inflammatory disease.
Url:
DOI: 10.1016/0192-0561(82)90009-1
Affiliations:
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Binderup</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup</wicri:regionArea><wicri:noRegion>DK-2750 Ballerup</wicri:noRegion></affiliation></author><author><name sortKey="Bramm, E" sort="Bramm, E" uniqKey="Bramm E" first="E." last="Bramm">E. Bramm</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup</wicri:regionArea><wicri:noRegion>DK-2750 Ballerup</wicri:noRegion></affiliation></author><author><name sortKey="Arrigoni Martelli, E" sort="Arrigoni Martelli, E" uniqKey="Arrigoni Martelli E" first="E." last="Arrigoni-Martelli">E. Arrigoni-Martelli</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup</wicri:regionArea><wicri:noRegion>DK-2750 Ballerup</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Immunopharmacology</title><title level="j" type="abbrev">IMMP</title><idno type="ISSN">0192-0561</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982">1982</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="57">57</biblScope><biblScope unit="page" to="66">66</biblScope></imprint><idno type="ISSN">0192-0561</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0192-0561</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetylsalicylic</term><term>Acetylsalicylic acid</term><term>Adherent</term><term>Adherent cells</term><term>Adjuvant</term><term>Adjuvant arthritis</term><term>Adjuvant disease</term><term>Antirheumatic</term><term>Antirheumatic drugs</term><term>Arthritic</term><term>Arthritic lewis rats</term><term>Arthritic rats</term><term>Arthritis</term><term>Arthritis rheum</term><term>Aurothiomalate</term><term>Binderup</term><term>Bramm</term><term>Ceils</term><term>Cell suspensions</term><term>Cell viability</term><term>Chloroquine</term><term>Chronic inflammation</term><term>Concanavalin</term><term>Control rats</term><term>Corresponding values</term><term>Days treatment</term><term>Immunological</term><term>Immunological reactivity</term><term>Immunological responsiveness</term><term>Indomethacin</term><term>Inflammation</term><term>Inhibitory effects</term><term>Levamisole</term><term>Lewis rats</term><term>Lymphocyte</term><term>Lymphocyte responsiveness</term><term>Macrophage</term><term>Mitogen</term><term>Myocrisin</term><term>Nonadherent</term><term>Nonadherent cells</term><term>Nonarthritic</term><term>Nonarthritic rats</term><term>Noninjected</term><term>Open bars</term><term>Plastic petri dishes</term><term>Polyarthritic lesions</term><term>Present experiments</term><term>Pyritinol</term><term>Rat</term><term>Rats nonarthritic nonarthritic</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Separate experiments</term><term>Sodium aurothiomalate</term><term>Spleen</term><term>Spleen cell responsiveness</term><term>Spleen cell suspensions</term><term>Spleen cells</term><term>Suppressive</term><term>Suppressive activity</term><term>Suppressive macrophages</term><term>Suppressor</term><term>Suppressor cells</term><term>Unseparated</term><term>Unseparated spleen cells</term><term>Untreated</term><term>Untreated rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: During the course of adjuvant arthritis in rats adherent spleen cells inhibited the response of spleen lymphocytes to the T-cell mitogen concanavalin A (Con A). The effects of 14 days treatment with various antirheumatic drugs on spleen cell responsiveness to Con A were investigated. Two nonsteroidal anti-inflammatory drugs, indomethacin (1 mg/kg/day p.o.) and acetylsalicylic acid (200 mg/kg/day p.o.) did not modify the spleen cell response, whereas treatment with chloroquine (50 mg/kg/day p.o.) or levamisole (5 mg/kg/day p.o.) further increased the inhibitory effects of the adherent suppressive spleen cells. On the contrary, treatment with sodium aurothiomalate (10 mg/kg/day i.m.), D-penicillamine (50 mg/kg/day p.o.) or pyritinol (50 mg/kg/day p.o.) significantly enhanced the response of th e lymphocytes to Con A. In addition to the effects on spleen cell responsiveness, the ability of the various drug treatments to modify the polyarthritic lesions of the disease was investigated. It is suggested that this model may provide a valuable approach for evaluating the effects of antirheumatic drugs in vivo on immunological responsiveness during chronic inflammatory disease.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Binderup, L" sort="Binderup, L" uniqKey="Binderup L" first="L." last="Binderup">L. Binderup</name></noRegion><name sortKey="Arrigoni Martelli, E" sort="Arrigoni Martelli, E" uniqKey="Arrigoni Martelli E" first="E." last="Arrigoni-Martelli">E. Arrigoni-Martelli</name><name sortKey="Bramm, E" sort="Bramm, E" uniqKey="Bramm E" first="E." last="Bramm">E. Bramm</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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